Fig. 8

Effects of VMN nNOS siRNA Pretreatment on Eu- and Hypoglycemic Patterns of G-Protein-Coupled-81 (GPR81) Gene Expression in VMNdm versus VMNvl GABAergic Neurons. Plots depict normalized GPR81 [Fig. 8A (VMNdm) and 8B (VMNvl)] for GABAergic nerve cells acquired from subjects in the following treatment groups: SCR siRNA/sc V (blue box-and-whisker plots, n = 12), nNOS siRNA/sc V (yellow box-and-whisker plots; n = 12), SCR siRNA/ sc INS (green box-and-whisker plots; n = 12), or nNOS siRNA/sc INS (orange box-and-whisker plots; n = 12) treatment groups. Statistical differences between individual pairs of treatment groups are indicated by the following symbols: *p < 0.05; **p < 0.01; ***p < 0.001