Fig. 5

A small number of nodes occupy a distinct connectivity space: the “rich broker club.” A Principal component analysis for dimensionality reduction and k-means clustering parses out one cluster (blue, “Cluster 2”) that is distinctly different from the others. B Comparison of the observed (black solid line) and random mean (blue dotted line) relationships between rich club coefficients and degree. The point at which an observed relationship exits the standard deviation (blue shading) of the random mean marks the degree threshold above which nodes in our network are connected more than what would be expected in a randomly connected network of the same size (48, arrowhead). C Nodes plotted by betweenness centrality and degree separate the same cluster of nodes revealed in A, which we deem the “rich broker club.” See additional files for a table of these and other values for each node (Additional file 3). D Anatomical connections between the members of the rich broker club. Nodes are colored based on community membership and organized by superstructure. In-degree (E) and out-degree (F) of each member of the rich broker club are represented as stacked bar plots grouped by community. Bars are organized with each node's highest community degree value closest to the x-axis, followed by the second-highest, and so on