Fig. 4

Internetwork SC-FC coupling changes in PD. Statistical analysis revealed altered internetwork SC-FC coupling strength in 9 pairs of modules. Specifically, the coupling strength between SUB and VIS networks; SOM and DOR, VEN; DOR and DMN, FPC, VEN networks; DMN and FPC and LIM networks decreased in PD, while increased internetwork coupling was found between the SUB and SOM network. The coupling strength between DOR and DMN was correlated with UPDRS III scores (r = -0.276, p = 0.0455, uncorrected). Edges with warm and cool colors in the wheel represent increased and decreased coupling values. The size of the edges reflects the t values for coupling associated with significant alteration in PD. Cohen’s d value is shown around the distribution. VIS, visual network; SOM, somatomotor network; DOR, dorsal attention network; VEN, ventral attention network; LIM, limbic network; FPC, frontoparietal control network; DMN, default mode network; SUB, subcortical network. * denotes statistically significant results (p < 0.05, FDR corrected)