Fig. 1

Aging pattern of global entropy in the human cerebral cortex. Five repeated measures of the global SampEn for each participant are connected into individual background blue thin lines. Model fitted by GAMM generated the heavy blue dash line and blue line segments. These line segments extending from the blue dash line indicate the within-subject changes from five different age cohorts (58, 62, 66, 70, and 74 years of age at baseline), the aging curves. The dashed blue curve represents age-related changes of global entropy while the dashed red segment indicates the cohort effect