Fig. 6
From: The antioxidative effect of STAT3 involved in cellular vulnerability to isoflurane
Graphical summary of the protective effects of STAT3 in susceptibility to isoflurane-induced neurotoxicity. Isoflurane exposure increased calcineurin activity, a protein phosphatase that specifically promotes STAT3 degradation, in immature brain or neuron. The neuroprotective effects of STAT3 are mediated not only through its transcriptional activity, which upregulates anti-oxidative and anti-apoptotic proteins, but also through its mitochondrial function, which reduces ROS generation