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Fig. 3 | BMC Neuroscience

Fig. 3

From: ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans (C. elegans)

Fig. 3

Neuroprotection against 10 µM NMDA-insult in organotypic hippocampal slice cultures with different concentrations of ZA-II-05 (10 mM, 10 μM, 100 Mm). The data analysis revealed that ZA-II-05 exhibited a significant neuroprotective effect at a concentration of 100 µM and 100 mM, as indicated by a notable decrease in propidium iodide fluorescence intensity compared to the NMDA-treated group. The significance of the observed difference was denoted by the symbol “*”, indicating a statistically significant distinction (P < 0.05) compared to the NMDA group. Moreover, the comparison between the 100 mM group and the NMDA group showed a further reduction in propidium iodide fluorescence intensity, signified by the symbol “*”, also indicating a statistically significant difference (P < 0.05)

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BMC Neuroscience

ISSN: 1471-2202

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