Fig. 4

Signaling pathways of cell-to-cell communication analysis. (A) Comparison of the signaling pathway flow between Alzheimer’s and control. The flow is defined as the summation of the ligand-receptor gene expression products of that specific pathway across all sender-receiver pairs. Red indicates an increased communication in Alzheimer’s (while blue indicates decreased). (B) Communication strength difference among cell types in the pathway WNT. Red indicates an increased communication in Alzheimer’s (while blue indicates decreased). (C) Communication strength difference among cell types in the pathway CSF. (D) Communication strength difference among cell types in the pathway TGFβ. (E) Communication strength difference among cell types in the pathway CX3C