Fig. 3

Cell-type centric cell-to-cell communication analysis. (A) Differential network and boxplot of the outgoing cell-to-cell communication between Alzheimer’s and control. The nodes of the network were colored by the difference aggregated across signaling pathways. Red indicates an increased communication in Alzheimer’s (while blue indicates decreased). (B) Similar to A. Differential network and boxplot of the incoming cell-to-cell communication between Alzheimer’s and control. (C) Clustered heatmap of the cell-to-cell communication between all pair-wise cell types. Red indicates an increased communication in Alzheimer’s (while blue indicates decreased)