Fig. 1

Data overview. (A) Schematic of the Accelerating Medicines Partnership Program for Alzheimer’s Disease Consortium Data. (B) UMAP-embedding of the single-cell data labeled by cell type. (C) Table of marker genes for each cell type. (D) Schematic of the cell-to-cell communication analysis performed in the paper. Example of one communication (i.e. L5 to OPC) is highlighted. (E) The data structure of our cell-to-cell communication analysis. It is a three-dimensional matrix representing the communication strength between any sender and receiver cell type pair via a specific ligand-receptor pair. The L5 to OPC is an example array in our communication matrix. (F) An overall cell-to-cell communication network, with an example that highlights the signaling from L5 neuron to OPC glial cell