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Fig. 6 | BMC Neuroscience

Fig. 6

From: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats

Fig. 6

Sevoflurane can increase the mRNA expression of NLRP3 inflammasome and its downstream related proteins and inflammatory indicators in the prefrontal region of rats. A–D Transcript mRNA levels of NLRP3, Caspase-1 IL-1β, and IL-18 in the prefrontal cortex. Ctrl values are represented as blank control normalized values. The other values are fold changes relative to the blank control mean, suggesting that sevoflurane increased the mRNA expression of brain inflammation-related proteins and aggravated neuroinflammation. *Compared with the Ctrl group, P < 0.05; #compared with the Sev/3-MA group, P < 0.05

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BMC Neuroscience

ISSN: 1471-2202

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