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Fig. 3 | BMC Neuroscience

Fig. 3

From: Albumin alleviated esketamine-induced neuronal apoptosis of rat retina through downregulation of Zn2+-dependent matrix metalloproteinase 9 during the early development

Fig. 3

Time-dependent release of zinc after esketamine exposure. A Representative images show Zn2+ accumulation visualized in the whole-mount retina by the fluorescent Zn2+ sensor zinpyr-1. All images were taken at the same exposure. The image in the white dotted box is magnified as indicated with arrows. Scale bar, 100 μm. B The summary graph quantifies the intensity of zinpyr-1 signal in the GCL (n = 4 retinas per group). Grey bar: control; red bar: eyeballs exposure to esketamine for 3 h, 5 h and 7 h individually; blue bar: eyeballs exposure to TPEN and esketamine for 5 h. One-way ANOVA with Bonferroni post hoc tests. *** P < 0.001 compared with controls; ††† P < 0.001 compared with 5 h esketamine exposure

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BMC Neuroscience

ISSN: 1471-2202

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