Fig. 7

Mechanism diagram. The molecular mechanism of LSD1 in OGD/R-induced pyroptosis of RGCs. LSD1 downregulated miR-21-5p via demethylating H3K4me2 on the miR-21-5p promoter, which inhibited the binding of miR-21-5p to NLRP12 and further upregulated NLRP12, finally promoting pyroptosis of OGD/R-induced RGCs