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Fig. 3 | BMC Neuroscience

Fig. 3

From: Chronic constriction injury-induced changes in circular RNA expression profiling of the dorsal root ganglion in a rat model of neuropathic pain

Fig. 3

Differentially expressed circRNAs in dorsal root ganglions between the negative control and chronic constriction injury model. a Scatter plots showing circular RNA (circRNA) expression differences in the L4–L5 dorsal root ganglions (DRGs) of chronic constriction injury (CCI) rats with respect to the negative control (NC) group. n = 4/group. The circRNAs above the top red line or below the bottom red line indicated differential circRNAs (fold change ≥ 2 or ≤ 0.5, and FDR < 0.001) respectively. b Volcano plot indicating differentially expressed circRNAs (DEcircRNAs) in the L4–L5 DRGs of CCI models. Red dots represent circRNAs with significant expression, whereas black dots represent circRNAs with no significant difference. c Heatmap of DEcircRNAs shows hierarchical clustering of DEcircRNAs of rats in the CCI group compared to the NC group. In the clustering analysis, upregulated and downregulated genes are shown in red and green, respectively. d The Venn diagram indicates the number of overlapping and distinct circRNAs between NC and CCI rats

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BMC Neuroscience

ISSN: 1471-2202

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