Fig. 7

Co-localization of CCL2-ir and neuron marker in cortex and CC of saline and LPS injected mice. A CCL2-ir positive (CCL2 panels, arrows) neuron like (NeuN panels, arrowheads) cells (insets) are mainly situated in cortical layer I ~ III in frontal cortex (Merged panels, arrow-arrowheads, insets). B Following system LPS, the number of CCL2-ir and NeuN co-labeled cells (Merged, arrow-arrowheads) appears to be increased and spread broader in the cortex. C, D The CCL2-ir and NeuN co-labeled cells (arrow-arrowheads and insets) are also visualized in the CC and the cingulate cortex above the CC, in both saline and LPS injected animals. Scare bar = 100 µm in all A–D