Fig. 3

Co-localization of CCL2-ir and GFAP labeling in cortex and CC of saline and LPS injected mice. A, B In the cortex of both saline and LPS injected mice, CCL2-ir and GFAP double labeled structures (arrow-arrowheads) are mainly located in perivascular area (CCL2 panels, arrows). While, in some cases, the CCL2-ir positive structure appears to be laying against to the GFAP labeling (A, GFAP Merged, arrowhead). C, D Similarly, co-localizations of CCL2-ir and GFAP labeling (insets, arrow-arrowheads) are predominantly surrounding the microvasculature like structures (CCL2 panels, arrow) in the CC of both saline and LPS injected mice. Scare bar = 100 µm in all A– D