Diagnosis of schizophrenia with functional connectome data: a graph-based convolutional neural network approach

Oh, Kang-Han; Oh, Il-Seok; Tsogt, Uyanga; Shen, Jie; Kim, Woo-Sung; Liu, Congcong; Kang, Nam-In; Lee, Keon-Hak; Sui, Jing; Kim, Sung-Wan; Chung, Young-Chul

doi:10.1186/s12868-021-00682-9

BMC Neuroscience

Table 8 Aberrant functional connections in patients with schizophrenia spectrum disorders

From: Diagnosis of schizophrenia with functional connectome data: a graph-based convolutional neural network approach

Brain region	t value	Effect size	p-unc	p- FDR	Brain region
SSDs > HCs
Left posterior cingulate gyrus	6.38	0.150	< 0.001	< 0.001	Left orbital inferior frontal gyrus
	5.17	0.130	< 0.001	< 0.001	Right orbital inferior frontal gyrus
	4.35	0.110	< 0.001	0.005	Left triangularis inferior frontal gyrus
Right posterior cingulate gyrus	6.33	0.140	< 0.001	< 0.001	Left orbital inferior frontal gyrus
	5.20	0.130	< 0.001	< 0.001	Right orbital inferior frontal gyrus
	4.24	0.099	< 0.001	0.007	Left triangularis inferior frontal gyrus
Left orbito medial frontal gyrus	4.72	0.130	< 0.001	0.002	Right orbital inferior frontal gyrus
	4.70	0.110	< 0.001	0.002	Right operculum inferior frontal gyrus
	4.24	0.120	< 0.001	0.007	Left orbital inferior frontal gyrus
Right orbito medial frontal gyrus	4.04	0.097	< 0.001	0.001	Left operculum inferior frontal gyrus
	3.82	0.090	< 0.001	0.001	Left triangularis inferior frontal gyrus
	3.40	0.081	< 0.001	0.001	Right triangularis inferior frontal gyrus
Left anterior cingulate gyrus	4.21	0.110	< 0.001	0.001	Left triangularis inferior frontal gyrus
	3.83	0.100	< 0.001	0.001	Right triangularis inferior frontal gyrus
	3.82	0.093	< 0.001	0.001	Left operculum inferior frontal gyrus
Right anterior cingulate gyrus	4.42	0.110	< 0.001	0.004	Left orbital inferior frontal gyrus
	3.78	0.094	< 0.001	0.001	Left triangularis inferior frontal gyrus
	3.48	0.091	< 0.001	0.001	Right triangularis inferior frontal gyrus
Left superior frontal gyrus	4.54	0.110	< 0.001	0.003	Right operculum inferior frontal gyrus
	4.37	0.110	< 0.001	0.005	Right triangularis inferior frontal gyrus
Left precuneus	4.19	0.100	< 0.001	0.008	Left orbital inferior frontal gyrus
Left angular gyrus	4.24	0.120	< 0.001	0.007	Left triangularis inferior frontal gyrus
Right cuneus	4.17	0.130	< 0.001	0.008	Left calcarine sulcus
Left calcarine sulcus	5.40	0.140	< 0.001	< 0.001	Left cerebellum 6
Left middle cingulate gyrus	4.73	0.110	< 0.001	0.002	Left triangularis inferior frontal gyrus
SSDs < HCs
Left putamen	−5.20	−0.120	< 0.001	< 0.001	Right insular cortex
Right putamen	−5.94	−0.140	< 0.001	< 0.001	Right insular cortex
	−5.20	−0.110	< 0.001	< 0.001	Left insular cortex
Left Heschl’s gyrus	−6.38	−0.160	< 0.001	< 0.001	Right Heschl’s gyrus
	−4.45	−0.110	< 0.001	0.004	Right superior temporal gyrus
Left superior temporal gyrus	−4.80	−0.140	< 0.001	0.001	Right superior temporal gyrus

Whole-brain thresholded at FDR corrected p < 0.01, FDR, False Discovery Rate; HCs, Healthy Controls; SSDs, Schizophrenia spectrum disorders

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