Fig. 1

Diabetes-induced nociceptive behavior in the rat formalin test. a Temporal courses of the nociceptive behavior observed after injection of 0.5% formalin into the dorsal hind paw of normoglycemic and diabetic rats 21 days after streptozotocin injection. b, c Nociceptive behavior induced by 0.5% formalin during first and second phase in normoglycemic (NG) and diabetic rats 7, 14 and 21 days after streptozotocin injection. Data are expressed as mean ± SEM for 6 animals. *Significantly different with respect to the normoglycemic group (NG), determined by one-way ANOVA followed by the Dunnett’s test with a P < 0.05