Figure 6
From: Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
Specificity of HIV protein neurotoxicity. Tat1-72 induced neurotoxicity was compared with two deletion mutants TatΔ48-56 and TatΔ31-61. While TatΔ48-56 showed partial attenuation of neurotoxicity, TatΔ31-61 showed complete obliteration. Similarly no neurotoxicity was noted when gp120 was substituted with alpha-2 HS-glycoprotein (a2-HS-gp).