Figure 1

Hyperthermia-induced γ oscillation. (A): Heating hippocampal slice to 38.2°C induced epileptiform-like spikes, followed by a slow spreading depression (SD) recorded by intracellular (V_in) and extracellular (V_ex) electrodes simultaneously. (B): Expanded time scale from (A) to show initial epileptiform-like spikes. (C): Distribution of frequency of initial epileptiform spikes in 24 experimental cases. (D): Gaussian-fitting shows a γ band frequency (30–80 Hz) distribution of hyperthermia-induced epileptiform spikes.